Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 12/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 10/20 | 0.51 |
| ▸ | AR | P10275 | 8/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | SHBG | P04278 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767943 | 0.76 | PGR (0.51) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8541047 | 0.76 | PGR (0.48) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8536181 | 0.75 | PGR (0.49) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8768109 | 0.75 | PGR (0.47) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL9226144 | 0.73 | CYP3A4 (0.69) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL7200581 | 0.73 | PGR (0.50) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8409143 | 0.72 | PGR (0.42) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL9019799 | 0.72 | NR3C1 (0.63) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL23131212 | 0.72 | PGR (0.56) | PGRNR3C1ARCYP3A4LMNA | |
| SCHEMBL8639950 | 0.72 | PGR (0.35) | PGRNR3C1ARCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843933-A | 11β-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-01 | — | — | US | disclosed |
| US-5728689-A | ANTIGESTAGENIC EFFECT | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-03-17 | — | — | US | disclosed |