Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
| ▸ | LAP3 | P28838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18270226 | 0.77 | ALDH1A1 (0.35) | LMNAMAPTPOLBHPGDXBP1 | |
| SCHEMBL7479973 | 0.72 | LMNA (0.30) | LMNA | |
| SCHEMBL9175019 | 0.71 | LMNA (0.32) | LMNAHPGDALDH1A1ANPEPLAP3 | |
| SCHEMBL1695051 | 0.70 | HTT (0.41) | ALDH1A1 | |
| SCHEMBL8581966 | 0.66 | LMNA (0.32) | LMNAANPEPLAP3 | |
| SCHEMBL7125431 | 0.66 | ALDH1A1 (0.32) | LMNAALDH1A1 | |
| SCHEMBL15973099 | 0.65 | LMNA (0.31) | LMNA | |
| SCHEMBL8003670 | 0.65 | ELANE (0.37) | LMNAPOLBALDH1A1 | |
| SCHEMBL272692 | 0.64 | NR1H2 (0.39) | LMNAMAPTALDH1A1 | |
| SCHEMBL15973097 | 0.64 | LMNA (0.30) | LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770598-A | ANTITUMOR AGENTS; REACTING WITH CARBONYL DIIMIDAZOLE AND AMIDOXIMES | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 1998-06-23 | — | — | US | disclosed |
| EP-0769012-A1 | TETRACYCLIC DERIVATIVES AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-04-23 | — | — | EP | disclosed |
| WO-1996001827-A1 | TETRACYCLIC DERIVATIVES AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-01-25 | — | — | WO | disclosed |