Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9711501 | 0.82 | ALDH1A1 (0.38) | ARG1KDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1937006 | 0.78 | SMN1; SMN2 (0.36) | KDM4ESMN1; SMN2ALDH1A1ESR1MAPT | |
| SCHEMBL2285950 | 0.73 | KMT2A (0.39) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL1829860 | 0.72 | ALDH1A1 (0.47) | ARG1KDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2488201 | 0.69 | ALDH1A1 (0.39) | ARG1KDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1829325 | 0.68 | ALDH1A1 (0.53) | ARG1KDM4EHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8307092 | 0.67 | HSP90AA1 (0.45) | KDM4ESMN1; SMN2 | |
| SCHEMBL27637354 | 0.65 | TLR8 (0.68) | ARG1ALDH1A1TLR8 | |
| SCHEMBL28280379 | 0.64 | CA12 (0.52) | LMNA | |
| SCHEMBL28281481 | 0.64 | CA12 (0.52) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750532-A | TETRAHYDROPYRIMIDINE-2,4-DIONE DERIVATIVES, VIRICIDES, ANTIINFLAMMATORY AGENTS, PAF INHIBITORS | SCHERING CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |
| US-5459144-A | Enterovirus and rhinovirus antiviral, antiinflammatory and antagonist of platelet activating factor | SCHERING CORPORATION (US) | 1995-10-17 | — | — | US | disclosed |
| US-5272167-A | Pharmaceutically active compounds | SCHERING CORPORATION (US) | 1993-12-21 | — | — | US | disclosed |
| WO-1991000858-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | SCHERING CORPORATION (US) | 1991-01-24 | — | — | WO | disclosed |
| EP-0407217-A1 | Pharmaceutically active compounds | SCHERING CORPORATION (US) | 1991-01-09 | — | — | EP | disclosed |