SCHEMBL2285950

SCHEMBL2285950

Cn1ccnc1OC(=O)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.39
CHRNB2 P17787 1/20 0.36
CHRNA4 P43681 1/20 0.36
TSHR P16473 1/20 0.35
LPO P22079 1/20 0.34
FDPS P14324 2/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
RAB9A P51151 4/20 0.33
NPC1 O15118 3/20 0.33
HDAC4 P56524 2/20 0.32
PKM P14618 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1937006 0.81 SMN1; SMN2 (0.36) KMT2ALPOFDPSKDM4EALDH1A1
SCHEMBL28386445 0.78 CHRNB2 (0.40) KMT2ACHRNB2CHRNA4LPOFDPS
SCHEMBL1682004 0.78 CHRNB2 (0.40) KMT2ACHRNB2CHRNA4LPOFDPS
SCHEMBL6673530 0.77 CHRNB2 (0.39) KMT2ACHRNB2CHRNA4TSHRLPO
SCHEMBL8536744 0.73 ARG1 (0.32) KDM4EALDH1A1SMN1; SMN2
SCHEMBL28324902 0.72 CHRNB2 (0.36) KMT2ACHRNB2CHRNA4LPOFDPS
SCHEMBL16991360 0.72 CHRNB2 (0.40) KMT2ACHRNB2CHRNA4LPOFDPS
SCHEMBL3012029 0.71 KMT2A (0.50) KMT2ATSHRKDM4EALDH1A1PKM
SCHEMBL2804720 0.70 KMT2A (0.52) KMT2ATSHRKDM4EALDH1A1PKM
SCHEMBL30831127 0.69 NAMPT (0.42) KMT2ATSHRLPOFDPSKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111435705-B Repairing agent and repairing method thereof and method for preparing photoelectric film 杭州纤纳光电科技有限公司 2023-04-07 CN claimed
US-20210147466-A1 IMPROVED PROCESSES FOR THE PREPARATION OF GUADECITABINE AND INTERMEDIATES THEREOF TEVA CZECH INDUSTRIES S.R.O. (CZ) 2021-05-20 US claimed
EP-3634972-A2 IMPROVED PROCESSES FOR THE PREPARATION OF GUADECITABINE AND INTERMEDIATES THEREOF Teva Czech Industries s.r.o. (CZ) 2020-04-15 EP claimed
WO-2019014286-A2 IMPROVED PROCESSES FOR THE PREPARATION OF GUADECITABINE AND INTERMEDIATES THEREOF TEVA CZECH INDUSTRIES S.R.O. (CZ) 2019-01-17 WO claimed
CN-114502565-A Process for producing bicyclic phosphoramidites 第一三共株式会社 2022-05-13 CN disclosed
US-20210147466-A1 IMPROVED PROCESSES FOR THE PREPARATION OF GUADECITABINE AND INTERMEDIATES THEREOF TEVA CZECH INDUSTRIES S.R.O. (CZ) 2021-05-20 US disclosed
EP-3634972-A2 IMPROVED PROCESSES FOR THE PREPARATION OF GUADECITABINE AND INTERMEDIATES THEREOF Teva Czech Industries s.r.o. (CZ) 2020-04-15 EP disclosed
WO-2019014286-A2 IMPROVED PROCESSES FOR THE PREPARATION OF GUADECITABINE AND INTERMEDIATES THEREOF TEVA CZECH INDUSTRIES S.R.O. (CZ) 2019-01-17 WO disclosed
EP-1828218-B1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2014-04-30 EP disclosed
US-20130303745-A1 Synthesis of oligonucleotides LANGE MEINOLF (DE) 2013-11-14 US disclosed
US-20130281682-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2013-10-24 US disclosed
US-20120316328-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2012-12-13 US disclosed
EP-2152723-A1 SYNTHESIS OF OLIGONUCLEOTIDES Girindus AG (DE) 2010-02-17 EP disclosed
WO-2009066883-A1 ADHESIVE COMPOSITION, AND OPTICAL MEMBER, SURFACE PROTECTIVE SHEET CHEIL INDUSTRIES INC. (KR) 2009-05-28 WO disclosed
WO-2008141682-A1 SYNTHESIS OF OLIGONUCLEOTIDES GIRINDUS AG (DE) 2008-11-27 WO disclosed
EP-1828218-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR Girindus AG (DE) 2007-09-05 EP disclosed
CN-1840600-A Adhesive composition, adhesive sheets and surface protective film NITTO DENKO CORP (JP) 2006-10-04 CN disclosed
WO-2006064039-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR GIRINDUS AG (DE) 2006-06-22 WO disclosed
EP-0737358-A1 PHOTOELECTROCHEMICAL CELL AND ELECTROLYTE THEREFOR ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 1996-10-16 EP disclosed
WO-1995018456-A1 PHOTOELECTROCHEMICAL CELL AND ELECTROLYTE THEREFOR ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) 1995-07-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130303745-A1 Synthesis of oligonucleotides RNGTT, POLRMT, CPSF6 KMT2A 1057/4885CHRNB2 4634/4885CHRNA4 4264/4885
US-20120316328-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR ARAF, ATIC, PFKFB3 KMT2A 1546/4885CHRNB2 3727/4885CHRNA4 3490/4885
US-20210147466-A1 IMPROVED PROCESSES FOR THE PREPARATION OF GUADECITABINE AND INTERMEDIATES THEREOF UNG, SAMHD1, ALKBH1 KMT2A 853/4885CHRNB2 4882/4885CHRNA4 4850/4885
US-20130281682-A1 SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR ARAF, ATIC, HK2 KMT2A 1545/4885CHRNB2 3680/4885CHRNA4 3419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.