Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 9/20 | 0.46 |
| ▸ | ESR1 | P03372 | 8/20 | 0.46 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537911 | 0.83 | AMY1A (0.45) | ESR1NISCHCDK4CCNA2CCND1 | |
| SCHEMBL31429641 | 0.81 | GUSB (0.45) | NISCHCDK4CCNA2CCND1CDK2 | |
| SCHEMBL8540911 | 0.81 | GUSB (0.45) | NISCHCDK4CCNA2CCND1CDK2 | |
| SCHEMBL29466815 | 0.81 | NISCH (0.58) | NISCHMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL4775732 | 0.81 | NISCH (0.58) | NISCHMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL5914842 | 0.79 | ADRA2A (0.49) | NISCHMEN1ALDH1A1KMT2ASMPD3 | |
| SCHEMBL15152912 | 0.79 | NISCH (0.46) | NISCHMTORADKBRD4 | |
| SCHEMBL15651168 | 0.79 | NISCH (0.46) | NISCHMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL2455067 | 0.79 | NISCH (0.46) | NISCHMEN1ALDH1A1KMT2ASMPD3 | |
| SCHEMBL28654223 | 0.78 | NISCH (0.50) | NISCHCDK4CCNA2CCND1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |