Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | MGLL | Q99685 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3305635 | 0.85 | HSD11B1 (0.77) | HSD11B1KDM4EMGLLPOLBGAA | |
| SCHEMBL6236172 | 0.85 | HSD11B1 (1.00) | HSD11B1KDM4EMGLLPOLBGAA | |
| SCHEMBL13314119 | 0.85 | MGLL (0.64) | HSD11B1MGLLPOLBGAAALDH1A1 | |
| SCHEMBL16333619 | 0.84 | HSD11B1 (0.74) | HSD11B1KDM4EMGLLPOLBGAA | |
| SCHEMBL10274624 | 0.83 | ACHE (0.70) | HSD11B1KDM4EMGLLPOLBGAA | |
| SCHEMBL3614803 | 0.83 | ACHE (0.70) | HSD11B1MGLLALDH1A1SMN1; SMN2EPHX2 | |
| SCHEMBL13629805 | 0.83 | GAA (0.74) | HSD11B1MGLLGAAEPHX2MEN1 | |
| SCHEMBL6209947 | 0.82 | HSD11B1 (1.00) | HSD11B1KDM4EMGLLPOLBGAA | |
| SCHEMBL30967272 | 0.81 | HSD11B1 (0.71) | HSD11B1KDM4EMGLLPOLBGAA | |
| SCHEMBL6985975 | 0.80 | CA12 (0.71) | HSD11B1KDM4EPOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537201-B1 | 1-[4-(IMIDAZOL-1-YL)BENZOYL]PIPERIDINE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | SCHERING AG (DE) | 1998-11-18 | — | — | EP | disclosed |
| US-5189036-A | Cardiovascular agents; class III antiarrhythmic agents | SCHERING AG (DE) | 1993-02-23 | — | — | US | disclosed |