Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537242 | 0.87 | PPARG (0.46) | ADRA1ACSNK1A1TYRO3DYRK1BPDE5A | |
| SCHEMBL8541110 | 0.84 | FABP4 (0.49) | ADRA1ATBXAS1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL8538135 | 0.84 | FABP4 (0.49) | ADRA1ATBXAS1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL8538071 | 0.83 | FABP4 (0.50) | ADRA1ATBXAS1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL27397039 | 0.79 | KDM4E (0.56) | CYP4F2CYP4A11SMN1; SMN2 | |
| SCHEMBL8539809 | 0.79 | CYP4F2 (0.53) | CSNK1A1TYRO3DYRK1BCYP4F2CYP4A11 | |
| SCHEMBL3403159 | 0.77 | ADRA1A (0.58) | ADRA1ACSNK1A1TYRO3DYRK1BPDE5A | |
| SCHEMBL8538145 | 0.76 | ADRA1A (0.52) | ADRA1ACSNK1A1TYRO3DYRK1BPDE5A | |
| SCHEMBL8541667 | 0.76 | ADRA1A (0.52) | ADRA1ACSNK1A1TYRO3DYRK1BPDE5A | |
| SCHEMBL10950023 | 0.75 | DHFR (0.47) | TBXAS1CYSLTR2CYSLTR1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |