Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 15/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543882 | 0.91 | TBXAS1 (0.67) | TBXAS1TBXA2RALDH1A1 | |
| SCHEMBL8541174 | 0.86 | TBXAS1 (0.54) | TBXAS1MEN1KMT2A | |
| SCHEMBL8543738 | 0.85 | TBXAS1 (0.51) | TBXAS1TBXA2RSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8545966 | 0.80 | TBXAS1 (0.78) | TBXAS1TBXA2RALDH1A1 | |
| SCHEMBL8543137 | 0.79 | TLR7 (0.42) | TBXAS1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8538702 | 0.78 | TBXAS1 (0.64) | TBXAS1TBXA2R | |
| SCHEMBL8542938 | 0.78 | TBXAS1 (0.66) | TBXAS1 | |
| SCHEMBL8543710 | 0.76 | TBXAS1 (0.62) | TBXAS1TBXA2RMEN1KMT2A | |
| SCHEMBL8543376 | 0.76 | AURKA (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8544758 | 0.75 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | claimed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | claimed |