Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | NQO1 | P15559 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11273634 | 0.96 | CYP1A2 (0.50) | PTGS1AKR1C3AKR1C2CYP1A2KDM4E | |
| SCHEMBL6561661 | 0.84 | KDM4E (0.59) | CYP1A2KDM4ELMNAMAPTNPC1 | |
| SCHEMBL11272789 | 0.84 | CYP1A2 (0.51) | CYP1A2KDM4ENPC1RAB9APKM | |
| SCHEMBL13970023 | 0.83 | PTGS1 (0.47) | PTGS1AKR1C3AKR1C2CYP1A2KDM4E | |
| SCHEMBL8538723 | 0.82 | GLA (0.44) | AKR1C3AKR1C2CYP1A2KDM4ELMNA | |
| SCHEMBL9428551 | 0.82 | CYP1A2 (0.55) | PTGS1AKR1C3AKR1C2CYP1A2KDM4E | |
| 3-Methoxyphenylacetonitrile SCHEMBL103029 | 0.82 | PKM (0.61) | LMNAMAPTNPC1TP53CYP3A4 | |
| SCHEMBL11266053 | 0.82 | PIK3CD (0.40) | PTGS1AKR1C3AKR1C2CYP1A2KDM4E | |
| SCHEMBL10424390 | 0.81 | PTGS1 (0.57) | PTGS1AKR1C3AKR1C2CYP1A2KDM4E | |
| 3-Methoxyphenylacetonitrile SCHEMBL27728444 | 0.80 | PKM (0.59) | LMNAMAPTNPC1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107137387-B | Synthetic method of aryl propionic acid non-steroidal anti-inflammatory drug | 中国科学技术大学 | 2020-05-12 | — | — | CN | claimed |
| US-20160206605-A1 | COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-07-21 | — | — | US | claimed |
| US-20150045389-A1 | COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-12 | — | — | US | claimed |
| WO-2013155047-A2 | COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-10-17 | — | — | WO | claimed |
| EP-1549598-A4 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | CORTICAL PTY LTD (AU) | 2008-01-23 | — | — | EP | claimed |
| US-20060106102-A1 | Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) | Morand, Eric | 2006-05-18 | — | — | US | claimed |
| CN-1675154-A | Napththalene derivatives which inhibit the cytokine or biological activity of macrophage migration inhibitory factor (MIF) | CORTICAL PTY LTD (AU) | 2005-09-28 | — | — | CN | claimed |
| EP-1549598-A1 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | Cortical Pty Ltd (AU) | 2005-07-06 | — | — | EP | claimed |
| WO-2003104178-A1 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | CORTICAL PTY LTD (AU) | 2003-12-18 | — | — | WO | claimed |
| US-4894471-A | Continuous process for the alkylation of CH-acid compounds with alkyl carbonates in gas-liquid phase transfer catalysis-conditions | CONSIGLIO NAZIONALE DELLE RICHERCHE (IT) | 1990-01-16 | — | — | US | claimed |
| WO-2024174980-A1 | COMPOUND CONTAINING DIHYDROPHTHALAZINE AND ALKENYL AND USE THEREOF | 正大天晴药业集团股份有限公司 | 2024-08-29 | — | — | WO | disclosed |
| US-11639326-B2 | Continuous flow synthesis of ibuprofen | SRI INTERNATIONAL (US) | 2023-05-02 | — | — | US | disclosed |
| US-20210114962-A1 | CONTINUOUS FLOW SYNTHESIS OF IBUPROFEN | SRI INTERNATIONAL | 2021-04-22 | — | — | US | disclosed |
| CN-107137387-B | Synthetic method of aryl propionic acid non-steroidal anti-inflammatory drug | 中国科学技术大学 | 2020-05-12 | — | — | CN | disclosed |
| US-10322118-B2 | Compounds and methods for inhibiting Cif virulence factor | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2019-06-18 | — | — | US | disclosed |
| WO-2003104178-A1 | NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) | CORTICAL PTY LTD (AU) | 2003-12-18 | — | — | WO | disclosed |
| WO-2002098846-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-12-12 | — | — | WO | disclosed |
| EP-0240863-B1 | CONTINUOUS PROCESS FOR THE ALKYLATION OF CH-ACID COMPOUNDS WITH ALKYL CARBONATES IN GAS-LIQUID PHASE TRANSFER CATALYSIS CONDITIONS | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1991-10-09 | — | — | EP | disclosed |
| US-4894471-A | Continuous process for the alkylation of CH-acid compounds with alkyl carbonates in gas-liquid phase transfer catalysis-conditions | CONSIGLIO NAZIONALE DELLE RICHERCHE (IT) | 1990-01-16 | — | — | US | disclosed |
| EP-0240863-A1 | Continuous process for the alkylation of CH-acid compounds with alkyl carbonates in gas-liquid phase transfer catalysis conditions | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 1987-10-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160206605-A1 | COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR | CFTR, NCF1, CFB | PTGS1 1037/4885AKR1C3 3918/4885AKR1C2 4189/4885 |
| US-10322118-B2 | Compounds and methods for inhibiting Cif virulence factor | CFTR, NCF1, CFB | PTGS1 1037/4885AKR1C3 3918/4885AKR1C2 4189/4885 |
| US-20060106102-A1 | Napththalene derivatives which inhibit the cytokine or biological activity of microphage migration inhibitory factor (mif) | MIF, ARG1, MSR1 | PTGS1 103/4885AKR1C3 1224/4885AKR1C2 1475/4885 |
| US-20210114962-A1 | CONTINUOUS FLOW SYNTHESIS OF IBUPROFEN | PTGES2, PTGS2, PTGES | PTGS1 4/4885AKR1C3 284/4885AKR1C2 616/4885 |
| US-20150045389-A1 | COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR | CFTR, NCF1, CFB | PTGS1 1080/4885AKR1C3 3970/4885AKR1C2 4265/4885 |
| US-11639326-B2 | Continuous flow synthesis of ibuprofen | PTGES2, PTGS2, PTGES | PTGS1 4/4885AKR1C3 284/4885AKR1C2 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.