Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539149 | 0.80 | ALDH1A1 (0.53) | ALDH1A1CYP3A4KDM4ELMNAPOLB | |
| SCHEMBL3364644 | 0.77 | LMNA (0.50) | ALDH1A1PLAUKDM4ELMNAPOLB | |
| SCHEMBL8540048 | 0.75 | TSHR (0.52) | ALDH1A1TSHRHSD17B10CYP3A4KDM4E | |
| SCHEMBL27364792 | 0.74 | CYP3A4 (0.46) | ALDH1A1TSHRHSD17B10CYP3A4KDM4E | |
| SCHEMBL8541555 | 0.73 | ALDH1A1 (0.54) | ALDH1A1TSHRHSD17B10CYP3A4PLAU | |
| SCHEMBL6217194 | 0.73 | CYP3A4 (0.59) | ALDH1A1TSHRHSD17B10CYP3A4KDM4E | |
| SCHEMBL10465204 | 0.73 | MGAM (0.56) | ALDH1A1TSHRHSD17B10CYP3A4PLAU | |
| SCHEMBL8542799 | 0.73 | ALDH1A1 (0.53) | ALDH1A1TSHRHSD17B10CYP3A4KDM4E | |
| SCHEMBL5102454 | 0.72 | CYP3A4 (0.64) | ALDH1A1TSHRHSD17B10CYP3A4KDM4E | |
| SCHEMBL8539340 | 0.72 | ALDH1A1 (0.52) | ALDH1A1TSHRHSD17B10CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581500-B1 | Antibiotic carbapenem compounds | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5441949-A | Carbapenem antibiotic compounds | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | disclosed |
| EP-0581500-A1 | Antibiotic carbapenem compounds | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |