Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 8/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | BLM | P54132 | 5/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4656320 | 0.83 | ALDH1A1 (0.61) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL4656260 | 0.83 | ALDH1A1 (0.61) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL28791203 | 0.79 | EGFR (0.59) | KMT2AALDH1A1KDM4EPOLBEGFR | |
| SCHEMBL29538020 | 0.79 | EGFR (0.59) | KMT2AALDH1A1KDM4EPOLBEGFR | |
| SCHEMBL15298231 | 0.79 | MEN1 (0.55) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL8539278 | 0.79 | MAPT (0.55) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL15286783 | 0.78 | ALDH1A1 (0.50) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL2151553 | 0.77 | POLB (0.44) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL2151560 | 0.77 | POLB (0.44) | KMT2AALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL987696 | 0.77 | MAPT (0.77) | KMT2AALDH1A1MAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537949-B1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY CO ELI (GB) | 1998-07-01 | — | — | EP | disclosed |
| US-5284868-A | Naphthopyran derivatives; for autoimmune diseases, cancer | ELI LILLY AND COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| US-5281619-A | Administering naphtho(1,2-B)pyran derivatives | ELI LILLY AND COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0537949-A1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY INDUSTRIES LIMITED (GB) | 1993-04-21 | — | — | EP | disclosed |