Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 9/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | BLM | P54132 | 5/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15065094 | 0.86 | MAPT (0.55) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4656320 | 0.83 | ALDH1A1 (0.61) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8539257 | 0.79 | KMT2A (0.55) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL17466932 | 0.73 | MAPT (1.00) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9105604 | 0.73 | VCP (0.51) | KDM4ENPSR1TDP1NPC1RAB9A | |
| SCHEMBL9105595 | 0.73 | VCP (0.51) | KDM4ENPSR1TDP1NPC1RAB9A | |
| SCHEMBL11313166 | 0.72 | ALDH1A1 (0.70) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9591757 | 0.72 | MAPT (0.77) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3368837 | 0.72 | ALDH1A1 (0.77) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL11127611 | 0.72 | VCP (0.50) | KDM4ENPSR1TDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537949-B1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY CO ELI (GB) | 1998-07-01 | — | — | EP | disclosed |
| US-5284868-A | Naphthopyran derivatives; for autoimmune diseases, cancer | ELI LILLY AND COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| US-5281619-A | Administering naphtho(1,2-B)pyran derivatives | ELI LILLY AND COMPANY (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0537949-A1 | Antiproliferative derivatives of 4H-naphtho 1,2-b pyran | LILLY INDUSTRIES LIMITED (GB) | 1993-04-21 | — | — | EP | disclosed |