Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.61 |
| ▸ | MAPT | P10636 | 10/20 | 0.61 |
| ▸ | MEN1 | O00255 | 9/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 6/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 8/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | BLM | P54132 | 5/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539278 | 0.83 | MAPT (0.55) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL15065094 | 0.83 | MAPT (0.55) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL8539257 | 0.83 | KMT2A (0.55) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL26552253 | 0.81 | TRPA1 (0.47) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL15286935 | 0.80 | ALDH1A1 (0.52) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL17466932 | 0.78 | MAPT (1.00) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL12617223 | 0.78 | EGFR (0.70) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL3368837 | 0.77 | ALDH1A1 (0.77) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL11313166 | 0.77 | ALDH1A1 (0.70) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL20603132 | 0.77 | EGFR (0.64) | ALDH1A1KDM4ELMNAEGFRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | DREXEL UNIVERSITY | 2022-03-31 | — | — | US | disclosed |
| WO-2020146636-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING HEART FAILURE | DREXEL UNIVERSITY (US) | 2020-07-16 | — | — | WO | disclosed |
| WO-2020146636-A1 | COMPOUNDS AND METHODS FOR TREATING OR PREVENTING HEART FAILURE | DREXEL UNIVERSITY (US) | 2020-07-16 | — | — | WO | disclosed |
| EP-1385817-B1 | MALONONITRILE COMPOUNDS AND THEIR USE AS PESTICIDES | SUMITOMO CHEMICAL CO (JP) | 2008-12-03 | — | — | EP | disclosed |
| US-7402691-B2 | Malononitrile compounds and their use as pesticides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2008-07-22 | — | — | US | disclosed |
| US-7011838-B2 | Malononitrile compounds and their use as pesticides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-03-14 | — | — | US | disclosed |
| US-20050209323-A1 | Malononitrile compounds and their use as pesticides | OTAKA KEN | 2005-09-22 | — | — | US | disclosed |
| US-20040138065-A1 | Malononitrile compounds and their use as pesticides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220096450-A1 | Compounds and Methods for Treating or Preventing Heart Failure | SQOR, QSOX1, KEAP1 | ALDH1A1 411/4885KMT2A 677/4885MAPT 4525/4885 |
| US-20050209323-A1 | Malononitrile compounds and their use as pesticides | C1S, C1R, C5 | ALDH1A1 1502/4885KMT2A 3658/4885MAPT 4314/4885 |
| US-20040138065-A1 | Malononitrile compounds and their use as pesticides | CBR1, MAL2, CBR3 | ALDH1A1 614/4885KMT2A 2762/4885MAPT 4612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.