Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14962804 | 0.90 | HPGD (0.81) | HPGDSMN1; SMN2ALDH1A1MAPTALOX12 | |
| SCHEMBL7845225 | 0.88 | HPGD (0.56) | HPGDSMN1; SMN2ALDH1A1MAPTALOX12 | |
| SCHEMBL1976948 | 0.83 | HPGD (0.71) | HPGDSMN1; SMN2ALDH1A1MAPTALOX12 | |
| SCHEMBL22854085 | 0.83 | HPGD (0.71) | HPGDSMN1; SMN2ALDH1A1MAPTALOX12 | |
| SCHEMBL764569 | 0.83 | HPGD (0.71) | HPGDSMN1; SMN2ALDH1A1MAPTALOX12 | |
| SCHEMBL178376 | 0.82 | HPGD (1.00) | HPGDSMN1; SMN2ALDH1A1MAPTALOX12 | |
| SCHEMBL11727915 | 0.82 | ALDH1A1 (0.63) | HPGDSMN1; SMN2ALDH1A1MAPTRAB9A | |
| SCHEMBL3037762 | 0.82 | L3MBTL1 (0.51) | HPGDSMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL10238819 | 0.82 | ALDH1A1 (0.71) | HPGDSMN1; SMN2ALDH1A1MAPTRAB9A | |
| SCHEMBL5347276 | 0.81 | RAB9A (0.53) | HPGDSMN1; SMN2ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230141403-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-05-11 | — | — | US | disclosed |
| EP-4161930-A1 | NOVEL IMIDAZO-PYRAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-04-12 | — | — | EP | disclosed |
| CN-115667264-A | Novel imidazo-pyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |
| WO-2021249893-A1 | NOVEL IMIDAZO-PYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-16 | — | — | WO | disclosed |
| CN-108530444-B | Novel NAMPT and IDO dual inhibitor and preparation method and medical application thereof | 药康众拓(江苏)医药科技有限公司 | 2021-08-24 | — | — | CN | disclosed |
| EP-3008045-B1 | ANTIBACTERIAL THIAZOLECARBOXYLIC ACIDS | ANTABIO SAS (FR) | 2018-05-09 | — | — | EP | disclosed |
| US-8901315-B2 | Thienopyrazole derivative having PDE7 inhibitory activity | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-12-02 | — | — | US | disclosed |
| US-8901315-B2 | Thienopyrazole derivative having PDE7 inhibitory activity | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-12-02 | — | — | US | disclosed |
| US-8901315-B2 | Thienopyrazole derivative having PDE7 inhibitory activity | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-12-02 | — | — | US | disclosed |
| US-8802448-B2 | Mixed mode ligands | PALL CORPORATION (US) | 2014-08-12 | — | — | US | disclosed |
| WO-2000018734-A1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-04-06 | — | — | WO | disclosed |
| EP-0922034-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS EAA ANTAGONISTS | GLAXO WELLCOME S.p.A. (IT) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998007704-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS EAA ANTAGONISTS | GLAXO WELLCOME S.P.A. (IT) | 1998-02-26 | — | — | WO | disclosed |
| US-4742160-A | CATIONIC DYES; PRINTING | SANDOZ LTD. (CH) | 1988-05-03 | — | — | US | disclosed |
| EP-0087706-B1 | CATIONIC HYDRAZONE DYES, THEIR MANUFACTURE AND THEIR USE | BAYER AG (DE) | 1986-07-30 | — | — | EP | disclosed |
| US-4496719-A | 3H-Indol-2-yl cationic hydrazone dyestuffs | BAYER AKTIENGESELLSCHAFT (DE) | 1985-01-29 | — | — | US | disclosed |
| EP-0087706-A2 | Cationic hydrazone dyes, their manufacture and their use | BAYER AG (DE) | 1983-09-07 | — | — | EP | disclosed |
| US-4224448-A | FUNGICIDES, BACTERICIDES | HABER RAPHAEL R G | 1980-09-23 | — | — | US | disclosed |
| US-4220586-A | FASTNESS TO LIGHT, OVER-LACQUERING, MIGRATION, WEATHERING, AND HEAT | CIBA-GEIGY CORPORATION (US) | 1980-09-02 | — | — | US | disclosed |
| US-4080321-A | COLORFASTNESS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230141403-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | XDH, MYD88, IKZF3 | HPGD 1801/4885SMN1; SMN2 2032/4885ALDH1A1 2986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.