Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 9/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 8/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541387 | 1.00 | ABCB1 (0.40) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8544061 | 1.00 | ABCB1 (0.40) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8537722 | 0.81 | ABCC9 (0.55) | ABCB1ABCC9 | |
| SCHEMBL8589788 | 0.81 | KDM4E (0.47) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8539686 | 0.81 | ABCC9 (0.55) | ABCB1ABCC9 | |
| SCHEMBL7358720 | 0.81 | ABCC9 (0.41) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7330766 | 0.80 | ABCB1 (0.40) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7325866 | 0.80 | ABCB1 (0.39) | ABCB1ABCC9KDM4E | |
| SCHEMBL7330716 | 0.77 | ABCB1 (0.41) | ABCB1ABCC9KDM4E | |
| SCHEMBL8536420 | 0.75 | ABCC9 (0.42) | ABCB1ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489327-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1998-05-27 | — | — | EP | claimed |
| US-5238937-A | PYRIDAZINY OR OXODIHYDROPYRIDAZINYL CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 1993-08-24 | — | — | US | claimed |
| EP-0489327-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1992-06-10 | — | — | EP | claimed |
| EP-0489327-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1998-05-27 | — | — | EP | disclosed |
| US-5238937-A | PYRIDAZINY OR OXODIHYDROPYRIDAZINYL CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 1993-08-24 | — | — | US | disclosed |
| EP-0489327-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1992-06-10 | — | — | EP | disclosed |