Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | OGT | O15294 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539179 | 0.90 | POLB (0.47) | MAPTGAAESR1MEN1KMT2A | |
| SCHEMBL8544817 | 0.89 | GAA (0.53) | MAPTGAAESR1BRD4MEN1 | |
| SCHEMBL8539413 | 0.78 | HTR6 (0.56) | MEN1KMT2AKDM4E | |
| SCHEMBL3367245 | 0.77 | IDO1 (0.59) | MAPTMEN1KMT2ACES1ALDH1A1 | |
| SCHEMBL6257664 | 0.74 | ESR1 (0.52) | MAPTSMN1; SMN2ESR1MEN1KMT2A | |
| SCHEMBL14018691 | 0.74 | MAPT (0.59) | MAPTGAAESR1BRD4MEN1 | |
| SCHEMBL14044801 | 0.73 | MAPT (0.55) | MAPTGAAESR1BRD4MEN1 | |
| SCHEMBL852679 | 0.73 | BACE1 (0.49) | SMN1; SMN2ALDH1A1HPGDKDM4EEGFR | |
| SCHEMBL8539417 | 0.73 | HTR6 (0.52) | MAPTTP53ALDH1A1HPGD | |
| SCHEMBL8172861 | 0.73 | MAPT (0.62) | MAPTSMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | claimed |