Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | ATIC | P31939 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539408 | 0.89 | MAPT (0.49) | GAAMAPTESR1BRD4MEN1 | |
| SCHEMBL9370958 | 0.81 | MMP2 (0.56) | FFAR1ALDH1A1 | |
| SCHEMBL8539179 | 0.78 | POLB (0.47) | GAAMAPTESR1MEN1KMT2A | |
| SCHEMBL8544819 | 0.78 | HTR6 (0.59) | GAAMAPTBRD4MEN1KMT2A | |
| SCHEMBL6257664 | 0.75 | ESR1 (0.52) | MAPTESR1MEN1KMT2AALDH1A1 | |
| SCHEMBL30222912 | 0.75 | SIRT1 (0.58) | MEN1KMT2AFFAR1SIRT1 | |
| SCHEMBL14018691 | 0.75 | MAPT (0.59) | GAAMAPTESR1BRD4MEN1 | |
| SCHEMBL14044801 | 0.74 | MAPT (0.55) | GAAMAPTESR1BRD4MEN1 | |
| SCHEMBL8172861 | 0.73 | MAPT (0.62) | MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4169893 | 0.73 | BRD4 (0.53) | GAAMAPTESR1BRD4PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | claimed |