Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537871 | 0.93 | HDAC1 (0.42) | TK1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL6523725 | 0.85 | KDM4E (0.48) | TK1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL5801330 | 0.85 | HDAC3 (0.40) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL19553815 | 0.82 | CNR2 (0.42) | TK1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL8157896 | 0.80 | CTSL (0.51) | — | |
| SCHEMBL19553607 | 0.80 | CNR2 (0.40) | TK1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL19553602 | 0.80 | HSP90AB1 (0.47) | HDAC1HDAC6HDAC4 | |
| SCHEMBL8539778 | 0.80 | CDK1 (0.49) | — | |
| SCHEMBL8538543 | 0.79 | HDAC1 (0.52) | HDAC1HDAC2HDAC8HDAC6YTHDC1 | |
| SCHEMBL19553675 | 0.76 | CNR2 (0.37) | TK1HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794781-A4 | DRUGS TO PREVENT RECURRENT HERPES VIRUS INFECTIONS | UNIV MASSACHUSETTS MEDICAL (US) | 1998-04-22 | — | — | EP | disclosed |
| EP-0794781-A1 | DRUGS TO PREVENT RECURRENT HERPES VIRUS INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5646155-A | ADMINISTERING A 9-SUBSTITUTED-N2-PHENYLGUANINE DERIVATIVE | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1996020711-A1 | DRUGS TO PREVENT RECURRENT HERPES VIRUS INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1996-07-11 | — | — | WO | disclosed |