Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | TK1 | P04183 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539832 | 0.93 | TK1 (0.46) | HDAC1HDAC2HDAC8HDAC6YTHDC1 | |
| SCHEMBL6523725 | 0.87 | KDM4E (0.48) | HDAC1HDAC2HDAC8HDAC6YTHDC1 | |
| SCHEMBL8539778 | 0.86 | CDK1 (0.49) | LMNAMAPK1 | |
| SCHEMBL8538543 | 0.81 | HDAC1 (0.52) | HDAC1HDAC2HDAC8HDAC6YTHDC1 | |
| SCHEMBL12537333 | 0.80 | P2RX7 (0.50) | HDAC1HDAC2HDAC8HDAC6YTHDC1 | |
| SCHEMBL8537887 | 0.78 | TK1 (0.68) | TK1 | |
| SCHEMBL5801330 | 0.78 | HDAC3 (0.40) | HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL19553815 | 0.73 | CNR2 (0.42) | HDAC1HDAC2HDAC8HDAC6TK1 | |
| SCHEMBL19690966 | 0.73 | CDK1 (0.45) | — | |
| SCHEMBL8157896 | 0.73 | CTSL (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794781-A4 | DRUGS TO PREVENT RECURRENT HERPES VIRUS INFECTIONS | UNIV MASSACHUSETTS MEDICAL (US) | 1998-04-22 | — | — | EP | disclosed |
| EP-0794781-A1 | DRUGS TO PREVENT RECURRENT HERPES VIRUS INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5646155-A | ADMINISTERING A 9-SUBSTITUTED-N2-PHENYLGUANINE DERIVATIVE | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1996020711-A1 | DRUGS TO PREVENT RECURRENT HERPES VIRUS INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1996-07-11 | — | — | WO | disclosed |