Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GPX4 | P36969 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539829 | 1.00 | NFE2L2 (0.43) | NFE2L2HCAR2KEAP1ALDH1A1HTT | |
| SCHEMBL14433154 | 0.84 | ALDH1A1 (0.50) | HCAR2ALDH1A1MAPTNAAA | |
| SCHEMBL2609703 | 0.83 | NAAA (0.44) | NFE2L2HCAR2KEAP1NAAA | |
| SCHEMBL4806256 | 0.79 | NAAA (0.44) | NAAA | |
| SCHEMBL4806247 | 0.79 | NAAA (0.44) | NAAA | |
| SCHEMBL14314397 | 0.77 | NFE2L2 (0.42) | NFE2L2HCAR2KEAP1ALDH1A1HTT | |
| SCHEMBL16090935 | 0.76 | KDM4E (0.40) | NFE2L2HCAR2KEAP1ALDH1A1MAPT | |
| SCHEMBL4812064 | 0.75 | NAAA (0.47) | MAPTNAAA | |
| SCHEMBL4812060 | 0.75 | NAAA (0.47) | MAPTNAAA | |
| SCHEMBL3362031 | 0.74 | NAAA (0.46) | MAPTNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6116250-A | — | — | None | — | — | JP | disclosed |
| EP-0358154-B1 | Novel cyclobutane derivative and process for producing same | NIPPON KAYAKU KK (JP) | 1998-12-02 | — | — | EP | disclosed |
| EP-0452729-B1 | Process for preparing substituted cyclobutanes | BRISTOL MYERS SQUIBB CO (US) | 1995-07-12 | — | — | EP | disclosed |
| US-5399775-A | Process for preparing substituted cyclobutanes | BRISTOL-MYERS SQUIBB CO. (US) | 1995-03-21 | — | — | US | disclosed |
| US-5312963-A | Process for preparing substituted cyclobutanes | BRISTOL-MYERS SQUIBB CO. (US) | 1994-05-17 | — | — | US | disclosed |
| JP-H06116250-A | PRODUCTION OF N-@(3754/24)2-ALKENOYL)-2-OXAZOLIDINONE DERIVATIVE | NIPPON KAYAKU CO LTD | 1994-04-26 | — | — | JP | disclosed |
| US-5250697-A | Drugs, perfumes, reagents, intermediates for viraicides | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1993-10-05 | — | — | US | disclosed |
| US-5235052-A | PROCESS FOR PREPARING SUBSTITUTED CYCLOBUTANE PURINES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-08-10 | — | — | US | disclosed |
| EP-0452729-A1 | Process for preparing substituted cyclobutanes | BRISTOL-MYERS SQUIBB COMPANY (US) | 1991-10-23 | — | — | EP | disclosed |
| EP-0444597-A1 | Novel cyclobutane derivative | Nippon Kayaku Kabushiki Kaisha (JP) | 1991-09-04 | — | — | EP | disclosed |
| WO-1990005730-A2 | NOVEL CYCLOBUTANE DERIVATIVE AND PROCESS FOR PRODUCING SAME | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1990-05-31 | — | — | WO | disclosed |
| EP-0358154-A2 | Novel cyclobutane derivative and process for producing same | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1990-03-14 | — | — | EP | disclosed |