Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8159013 | 0.98 | MEN1 (0.34) | MEN1KMT2APOLBATMSIGMAR1 | |
| Hydrochloric Acid SCHEMBL6904140 | 0.88 | SIGMAR1 (0.36) | MEN1KMT2ASIGMAR1KDM4EHTR2A | |
| Hydrochloric Acid SCHEMBL7899361 | 0.84 | SIGMAR1 (0.36) | MEN1KMT2ASIGMAR1KDM4EHTR2A | |
| SCHEMBL668104 | 0.84 | SIGMAR1 (0.38) | MEN1KMT2ASIGMAR1KDM4EHTR2A | |
| SCHEMBL29603716 | 0.84 | SIGMAR1 (0.38) | MEN1KMT2ASIGMAR1KDM4EHTR2A | |
| Lithium SCHEMBL8770699 | 0.82 | SIGMAR1 (0.37) | MEN1KMT2ASIGMAR1KDM4EHTR2A | |
| SCHEMBL6904952 | 0.82 | SIGMAR1 (0.37) | MEN1KMT2ASIGMAR1KDM4EHTR2A | |
| SCHEMBL9144863 | 0.82 | SIGMAR1 (0.37) | MEN1KMT2ASIGMAR1KDM4EHTR2A | |
| SCHEMBL9144870 | 0.82 | SIGMAR1 (0.37) | MEN1KMT2ASIGMAR1KDM4EHTR2A | |
| SCHEMBL8770693 | 0.82 | SIGMAR1 (0.37) | MEN1KMT2ASIGMAR1KDM4EHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710224-A | CATALYTIC POLYMERIZATION OF ETHYLENE USING FLUORENE INDENYL ETHANE ZIRCONIUM DICHLORIDE WITH METALLOCENE | PHILLIPS PETROLEUM COMPANY (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0729978-A1 | Polyethylene and method for production thereof | PHILLIPS PETROLEUM COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |