SCHEMBL8540217

SCHEMBL8540217

C=C(C)Cc1c(-n2c(=O)cc(C(F)(F)F)n(C)c2=O)ccc(Cl)c1O

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.30
LIPG Q9Y5X9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8545055 0.85 LIPG (0.32) LIPG
SCHEMBL8546283 0.82
SCHEMBL8176579 0.76 ALDH1A1 (0.38) LIPG
SCHEMBL9039291 0.74 KDM4E (0.41)
SCHEMBL8682441 0.73
SCHEMBL24241972 0.73
SCHEMBL7943436 0.73 PPOX (0.37)
SCHEMBL6799361 0.72 HCAR1 (0.39)
SCHEMBL1400120 0.72 GRM4 (0.32)
SCHEMBL7943759 0.72 NOTUM (0.33) TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617033-B1 Dihydrobenzofuran derivatives, their production and use SUMITOMO CHEMICAL CO (JP) 1998-08-12 EP disclosed
US-5411935-A Herbicides SUMITOMO CHEMICAL CO., LTD. (JP) 1995-05-02 US disclosed
EP-0617033-A1 Dihydrobenzofuran derivatives, their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-09-28 EP disclosed