SCHEMBL8540475

SCHEMBL8540475

CN1C(=O)C(NC(=O)Nc2cccc(-c3nnn[nH]3)c2)C(=O)N(c2ccccc2)c2ccccc21

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 18/20 0.51
CCKAR P32238 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1387823 0.88 CCKBR (0.70) CCKBRCCKAR
SCHEMBL1387798 0.88 CCKBR (0.70) CCKBR
SCHEMBL7754058 0.83 CCKAR (0.74) CCKBRCCKAR
SCHEMBL9422497 0.81 CCKBR (0.53) CCKBRCCKAR
SCHEMBL8542118 0.80 CCKBR (0.77) CCKBRCCKAR
SCHEMBL9251487 0.79 CCKBR (0.62) CCKBRCCKAR
SCHEMBL8545928 0.78 CCKBR (0.74) CCKBRCCKAR
SCHEMBL8547385 0.76 CCKBR (0.70) CCKBRCCKAR
SCHEMBL9699970 0.75 CCKBR (0.71) CCKBR
SCHEMBL9303173 0.75 CCKBR (0.71) CCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0698014-B1 3-PHENYLUREIDO-1,5-BENZODIAZEPINE-DIONES USEFUL AS GASTRIN OR CCK ANTAGONISTS GLAXO WELLCOME SPA (IT) 1998-07-22 EP disclosed
US-5641775-A 3-phenylureido-1,5-benzodiazepine-diones useful as gastrin or antagonists GLAXO SPA (IT) 1997-06-24 US disclosed