Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27337901 | 0.82 | PARP1 (0.35) | PARP1PRMT5MAOBPSMB8ELANE | |
| Lithium Ion SCHEMBL8537021 | 0.74 | SLC9A1 (0.35) | MEN1KMT2A | |
| SCHEMBL30474592 | 0.73 | PRMT5 (0.41) | PARP1PRMT5MAOBPSMB8POLB | |
| SCHEMBL13106159 | 0.72 | PARP1 (0.41) | PARP1PRMT5MAOBPSMB8ELANE | |
| SCHEMBL8538654 | 0.68 | PRMT5 (0.37) | PARP1PRMT5MAOBMEN1KMT2A | |
| SCHEMBL27359779 | 0.67 | PSMB8 (0.46) | PARP1PRMT5MAOBPSMB8 | |
| SCHEMBL27456009 | 0.67 | PRMT5 (0.36) | PARP1PRMT5MAOBPSMB8MEN1 | |
| SCHEMBL17950452 | 0.61 | SLC9A1 (0.43) | PARP1PRMT5ELANEKMT2A | |
| SCHEMBL28161565 | 0.60 | PDPK1 (0.44) | PRMT5ELANE | |
| SCHEMBL29993893 | 0.59 | SLC9A1 (0.32) | PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657450-B1 | INDAZOLESULFONYLUREA DERIVATIVE, USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF | KUMIAI CHEMICAL INDUSTRY CO (JP) | 1998-09-09 | — | — | EP | disclosed |
| US-5763616-A | HERBICIDES | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| US-5670452-A | PREEMERGENCE HERBICIDES | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| US-5534481-A | Indazolesulfonylurea derivative, its use and intermediate for its production | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-07-09 | — | — | US | disclosed |
| EP-0657450-A1 | INDAZOLESULFONYLUREA DERIVATIVE, USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF | KumaiI Chemical Industry Co., Ltd. (JP) | 1995-06-14 | — | — | EP | disclosed |