Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 8/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539005 | 0.92 | LMNA (0.41) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8539073 | 0.91 | ADRA1D (0.35) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8539076 | 0.87 | MAPT (0.36) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL8539065 | 0.86 | ADRA1D (0.35) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8540655 | 0.82 | ALDH1A1 (0.32) | AR | |
| SCHEMBL20228715 | 0.81 | ADRA1D (0.54) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL20228716 | 0.81 | ADRA1D (0.54) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8544336 | 0.80 | ADRA1D (0.44) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL20228858 | 0.79 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BADRB2HTR1A | |
| SCHEMBL8540605 | 0.79 | ADRA1D (0.39) | ADRA1DADRA1AADRA1BADRB2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600675-B1 | Indoline compounds for the treatment of dysuria | KISSEI PHARMACEUTICAL (JP) | 1998-07-08 | — | — | EP | disclosed |
| US-5387603-A | Treating dysuria (painful urination) with less hypotension; FDA Orange book listed patent for silodosin | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0600675-A1 | Indoline compounds for the treatment of dysuria | Kissei Pharmaceutical Co., Ltd. (JP) | 1994-06-08 | — | — | EP | disclosed |