Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 2/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | CASR | P41180 | 3/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541286 | 0.88 | ADRA1D (0.41) | ADRB1ADRB3ADRA1DADRA1AADRA1B | |
| SCHEMBL8539009 | 0.84 | LMNA (0.40) | ADRB1ADRB3ADRA1DADRA1AADRA1B | |
| SCHEMBL8539068 | 0.83 | ADRA1D (0.38) | ADRB1ADRB3ADRA1DADRA1AADRA1B | |
| SCHEMBL8540605 | 0.82 | ADRA1D (0.39) | ADRB1ADRB3ADRA1DADRA1AADRA1B | |
| SCHEMBL7902965 | 0.80 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BADRB2KCNH2 | |
| SCHEMBL8539078 | 0.79 | MAPT (0.35) | ADRA1DADRA1AADRA1BADRB2KCNH2 | |
| SCHEMBL8540655 | 0.77 | ALDH1A1 (0.32) | RXFP1ALDH1A1 | |
| SCHEMBL8544341 | 0.74 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BADRB2KCNH2 | |
| SCHEMBL8537726 | 0.73 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BADRB2KCNH2 | |
| SCHEMBL8539470 | 0.72 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BADRB2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600675-B1 | Indoline compounds for the treatment of dysuria | KISSEI PHARMACEUTICAL (JP) | 1998-07-08 | — | — | EP | disclosed |
| US-5387603-A | Treating dysuria (painful urination) with less hypotension; FDA Orange book listed patent for silodosin | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0600675-A1 | Indoline compounds for the treatment of dysuria | Kissei Pharmaceutical Co., Ltd. (JP) | 1994-06-08 | — | — | EP | disclosed |