Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540048 | 0.84 | TSHR (0.52) | ALDH1A1TSHRHSD17B10CYP3A4GABRP | |
| SCHEMBL1315731 | 0.77 | KDM4E (0.52) | ALDH1A1HSD17B10NCF1ACHEALOX15 | |
| SCHEMBL8546392 | 0.77 | ADORA3 (0.53) | ALDH1A1TSHRHSD17B10CYP3A4GABRP | |
| SCHEMBL14746991 | 0.76 | ALDH1A1 (0.55) | ALDH1A1TSHRHSD17B10CYP3A4GABRP | |
| SCHEMBL1314146 | 0.75 | ALOX15 (0.58) | ALDH1A1TSHRHSD17B10NCF1ACHE | |
| SCHEMBL8545253 | 0.74 | ALDH1A1 (0.47) | ALDH1A1TSHRHSD17B10CYP3A4GABRP | |
| SCHEMBL8540920 | 0.72 | ALDH1A1 (0.43) | ALDH1A1TSHRHSD17B10CYP3A4GABRP | |
| SCHEMBL11604488 | 0.72 | ALDH1A1 (0.57) | ALDH1A1TSHRHSD17B10CYP3A4GABRP | |
| SCHEMBL8541938 | 0.72 | ALDH1A1 (0.50) | ALDH1A1TSHRHSD17B10CYP3A4GABRP | |
| SCHEMBL6217194 | 0.72 | CYP3A4 (0.59) | ALDH1A1TSHRHSD17B10CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581500-B1 | Antibiotic carbapenem compounds | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5441949-A | Carbapenem antibiotic compounds | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | disclosed |
| EP-0581500-A1 | Antibiotic carbapenem compounds | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |