Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547776 | 0.87 | HTT (0.54) | AURKARPS6KB1HTTMAPK1APP | |
| SCHEMBL9382403 | 0.84 | AURKA (0.51) | AURKARPS6KB1HTTMAPK1APP | |
| SCHEMBL13456925 | 0.83 | AURKA (0.48) | AURKARPS6KB1HTTMAPK1APP | |
| SCHEMBL8546280 | 0.83 | GALR3 (0.51) | AURKARPS6KB1HTTMAPK1APP | |
| SCHEMBL8543977 | 0.83 | HTT (0.64) | AURKARPS6KB1HTTMAPK1APP | |
| SCHEMBL8544656 | 0.82 | CCNC (0.55) | AURKARPS6KB1HTTMAPK1APP | |
| SCHEMBL7506813 | 0.82 | KDM4E (0.48) | HTTEGFRLMNANFKB1NFKB2 | |
| SCHEMBL12340673 | 0.82 | OPRM1 (0.55) | AURKARPS6KB1HTTMAPK1APP | |
| SCHEMBL9303626 | 0.82 | PLAAT3 (0.48) | AURKARPS6KB1HTTMAPK1APP | |
| SCHEMBL8543007 | 0.82 | HTT (0.77) | AURKAHTTMAPK1APPEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5411963-A | Plant fungicides, miticides, insecticides | DOWELANCO (US) | 1995-05-02 | — | — | US | claimed |
| CN-1052379-C | Quinazoline derisatives | DOWELANCO (US) | 2000-05-17 | — | — | CN | disclosed |
| EP-0326329-B1 | Quinazoline derivatives useful as insecticides. | DOW AGROSCIENCES LLC (US) | 1998-10-28 | — | — | EP | disclosed |
| US-5411963-A | Plant fungicides, miticides, insecticides | DOWELANCO (US) | 1995-05-02 | — | — | US | disclosed |
| CN-1035825-A | Quinazoline derivant | LILLY CO ELI (US) | 1989-09-27 | — | — | CN | disclosed |