SCHEMBL8542467

SCHEMBL8542467

CC1C(=O)CC[C@]2(C)[C@@H]3CC[C@]4(C)C(C=O)CC[C@H]4[C@@H]3CCN12

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.41
GABRB2 P47870 1/20 0.41
SRD5A2 P31213 4/20 0.39
SRD5A1 P18405 7/20 0.36
CYP19A1 P11511 4/20 0.35
NR3C1 P04150 1/20 0.34
SHBG P04278 1/20 0.34
PGR P06401 1/20 0.34
SERPINA6 P08185 1/20 0.34
NR3C2 P08235 1/20 0.34
CYP3A4 P08684 1/20 0.34
AR P10275 1/20 0.34
GPBAR1 Q8TDU6 1/20 0.34
HSD17B10 Q99714 1/20 0.34
MGAM O43451 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8075351 0.83 SHBG (0.51) SRD5A2CYP19A1NR3C1SHBGPGR
SCHEMBL8075347 0.83 SHBG (0.51) SRD5A2CYP19A1NR3C1SHBGPGR
SCHEMBL8927033 0.77 AR (0.36) SRD5A2CYP19A1SHBGSERPINA6CYP3A4
SCHEMBL8726847 0.76 G6PD (0.42) SRD5A2GPBAR1
SCHEMBL8726845 0.76 G6PD (0.42) SRD5A2GPBAR1
SCHEMBL8926712 0.75 CYP19A1 (0.36) SRD5A2CYP19A1
SCHEMBL8927002 0.74 AR (0.39) SRD5A2SHBGPGRSERPINA6CYP3A4
SCHEMBL8926937 0.74 SRD5A2 (0.38) SRD5A2SHBGSERPINA6CYP3A4AR
SCHEMBL8927275 0.74 AR (0.37) SRD5A2SERPINA6CYP3A4ARGPBAR1
SCHEMBL8927180 0.73 AR (0.36) SRD5A2AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5760045-A BENIGN PROSTATIC HYPERPLASIA MERCK & CO., INC. (US) 1998-06-02 US disclosed
US-5693809-A PREGNANES FOR TREATING ALOPECIA, ACNE AND SKIN DISORDER MERCK & CO., INC. (US) 1997-12-02 US disclosed
EP-0646007-B1 NEW DELTA-17 AND DELTA-20 OLEFINIC AND SATURATED 17$g(b)-SUBSTITUTED-4-AZA-5$g(a)-ANDROSTAN-3-ONES AS 5$g(a)-REDUCTASE INHIBITORS MERCK & CO INC (US) 1997-08-13 EP disclosed
EP-0778284-A2 New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors MERCK & CO. INC. (US) 1997-06-11 EP disclosed
EP-0646007-A4 1995-04-26 EP disclosed
EP-0646007-A1 NEW DELTA-17 AND DELTA-20 OLEFINIC AND SATURATED 17-g(b)-SUBSTITUTED-4-AZA-5-g(a)-ANDROSTAN-3-ONES AS 5-g(a)-REDUCTASE INHIBITORS. MERCK & CO INC (US) 1995-04-05 EP disclosed
WO-1993023420-A1 NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO disclosed
WO-1993023050-A1 NEW DELTA-17 AND DELTA-20 OLEFINIC AND SATURATED 17β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO disclosed
WO-1993023039-A1 SUBSTITUTED 4-AZA-5A-ANDROSTAN-ONES AS 5A-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO disclosed