SCHEMBL854364

SCHEMBL854364

N#C/C(=C\C(=O)O)c1ccc(O)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.56
ESR2 Q92731 3/20 0.56
NQO2 P16083 1/20 0.51
ALDH1A1 P00352 2/20 0.46
MAPT P10636 2/20 0.46
KMT2A Q03164 1/20 0.46
CA2 P00918 3/20 0.45
CA1 P00915 2/20 0.45
CA12 O43570 1/20 0.45
CA3 P07451 1/20 0.45
TYR P14679 1/20 0.45
DRD1 P21728 1/20 0.45
CA4 P22748 1/20 0.45
CA6 P23280 1/20 0.45
CA5A P35218 1/20 0.45
CA7 P43166 1/20 0.45
CA9 Q16790 1/20 0.45
CA14 Q9ULX7 1/20 0.45
CA5B Q9Y2D0 1/20 0.45
HPGD P15428 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26827 1.00 ESR1 (0.56) ESR1ESR2NQO2ALDH1A1MAPT
SCHEMBL28093622 1.00 ESR1 (0.56) ESR1ESR2NQO2ALDH1A1MAPT
SCHEMBL28554503 1.00 ESR1 (0.56) ESR1ESR2NQO2ALDH1A1MAPT
Phosphoric Acid SCHEMBL5330100 0.93 ESR1 (0.50) ESR1ESR2NQO2ALDH1A1MAPT
Pyridine SCHEMBL1237058 0.89 ESR1 (0.46) ESR1ESR2NQO2ALDH1A1MAPT
Ether SCHEMBL27951660 0.87 NQO2 (0.45) ESR1ESR2NQO2ALDH1A1MAPT
Coumaric Acid SCHEMBL20261721 0.87 ESR1 (0.62) ESR1ESR2NQO2MAPTKMT2A
SCHEMBL22691970 0.86 TSHR (0.48) ESR1ESR2ALDH1A1KMT2ACA2
Gentisic Acid SCHEMBL28367375 0.85 PTGS2 (0.56) ESR1ESR2NQO2ALDH1A1KMT2A
SCHEMBL670068 0.84 ALDH1A1 (0.46) ALDH1A1MAPTKMT2ACA2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021087021-A1 PEPTIDE-NANOPARTICLE CONJUGATES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2021-05-06 WO disclosed
EP-2751128-B1 CELL-PENETRATING PEPTIDES HAVING A CENTRAL HYDROPHOBIC DOMAIN RES & INNOVATION UK (GB) 2021-03-03 EP disclosed
US-20180362611-A1 PEPTIDE AGONISTS OF GLP-1 ACTIVITY ZEALAND PHARMACEUTICALS A/S (DK) 2018-12-20 US disclosed
CN-103998458-B Cell-penetrating peptides with central hydrophibic domain 医学研究理事会 2018-10-09 CN disclosed
US-20170107267-A1 PEPTIDE AGONISTS OF GLP-1 ACTIVITY ZEALAND PHARMA A/S (DK) 2017-04-20 US disclosed
US-9302014-B2 Cell-penetrating peptides having a central hydrophobic domain MEDICAL RESEARCH COUNCIL (GB) 2016-04-05 US disclosed
US-RE45313-E1 Exendin variant peptides ZEALAND PHARMA A/S (DK) 2014-12-30 US disclosed
US-20140342992-A1 Cell-Penetrating Peptides Having a Central Hydrophobic Domain MEDICAL RESEARCH COUNCIL (GB) 2014-11-20 US disclosed
US-20140336356-A1 PEPTIDE AGONISTS OF GLP-1 ACTIVITY ZEALAND PHARMA A/S (DK) 2014-11-13 US disclosed
EP-2112161-B1 Peptides that lower blood glucose levels ZEALAND PHARMA AS (DK) 2014-11-05 EP disclosed
US-6897297-B1 Hydrophobically-modified protein compositions and methods CURIS, INC. (US) 2005-05-24 US disclosed
US-20040106547-A1 glucose lowering protein (GLP-1); exendins; for regulation of excess levels of blood glucose and/or regulation of gastric emptying; for treatment of diabetes and eating disorders ZEALAND PHARMA A/S 2004-06-03 US disclosed
EP-1329458-A2 Peptides that lower blood glucose levels Zealand Pharma A/S (DK) 2003-07-23 EP disclosed
EP-1196444-B1 EXTENDIN-4 CONJUGATES AND THEIR MEDICAL USE ZEALAND PHARMA AS (DK) 2003-06-04 EP disclosed
US-6569383-B1 Bioactive chip mass spectrometry INTRINSIC BIOPROBES, INC. 2003-05-27 US disclosed
US-6528486-B1 Conjugates which have increased stability, useful in the treatment of excess levels of blood glucose. ZEALAND PHARMA A/S (DK) 2003-03-04 US disclosed
EP-1076066-A1 Peptides for lowering blood glucose levels Zealand Pharmaceuticals A/S (DK) 2001-02-14 EP disclosed
EP-1062229-A1 PHARMACOLOGICALLY ACTIVE PEPTIDE CONJUGATES HAVING A REDUCED TENDENCY TOWARDS ENZYMATIC HYDROLYSIS Zealand Pharmaceuticals A/S (DK) 2000-12-27 EP disclosed
WO-1999046283-A9 PHARMACOLOGICALLY ACTIVE PEPTIDE CONJUGATES HAVING A REDUCED TENDENCY TOWARDS ENZYMATIC HYDROLYSIS ZEALAND PHARMACEUTICALS A S (DK) 1999-11-18 WO disclosed
WO-1999046283-A1 PHARMACOLOGICALLY ACTIVE PEPTIDE CONJUGATES HAVING A REDUCED TENDENCY TOWARDS ENZYMATIC HYDROLYSIS ZEALAND PHARMACEUTICALS A/S (DK) 1999-09-16 WO disclosed