SCHEMBL8544256

SCHEMBL8544256

Cc1cc(Oc2ccc(C#N)cc2)cc(Oc2ccc(C#N)cc2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
CYP2A6 P11509 1/20 0.52
AR P10275 5/20 0.51
PARP15 Q460N3 1/20 0.49
PARP10 Q53GL7 1/20 0.49
PARP2 Q9UGN5 1/20 0.49
LMNA P02545 3/20 0.47
CYP19A1 P11511 1/20 0.47
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
POLB P06746 1/20 0.47
MAPT P10636 1/20 0.47
PKM P14618 1/20 0.47
MAPK1 P28482 1/20 0.47
RAB9A P51151 1/20 0.47
KMT2A Q03164 1/20 0.47
IL18 Q14116 1/20 0.47
CACNA1G O43497 1/20 0.43
CACNA1B Q00975 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921658 0.96 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2CYP2A6ARPARP15
SCHEMBL29582194 0.89 PARP15 (0.57) ALDH1A1SMN1; SMN2CYP2A6ARPARP15
SCHEMBL459019 0.85 ALDH1A1 (0.73) ALDH1A1CYP2A6ARPARP15PARP10
SCHEMBL8546604 0.84 AR (0.51) ALDH1A1SMN1; SMN2ARPARP15PARP10
SCHEMBL17624244 0.83 KCNH2 (0.46) ALDH1A1SMN1; SMN2ARCYP19A1MEN1
SCHEMBL921433 0.83 AR (0.63) ALDH1A1CYP2A6ARPARP15PARP10
SCHEMBL31070296 0.83 AR (0.63) ALDH1A1CYP2A6ARPARP15PARP10
SCHEMBL8852392 0.82 PARP15 (0.63) ALDH1A1SMN1; SMN2CYP2A6ARPARP15
SCHEMBL7041250 0.82 PARP15 (0.63) ALDH1A1SMN1; SMN2CYP2A6ARPARP15
SCHEMBL924026 0.81 AR (0.55) ALDH1A1SMN1; SMN2CYP2A6ARPARP15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed