Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.78 |
| ▸ | DRD2 | P14416 | 4/20 | 0.78 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | DRD5 | P21918 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977889 | 0.94 | HTR1A (0.78) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL6509439 | 0.88 | DRD2 (1.00) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7991840 | 0.84 | DRD2 (0.82) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL11497577 | 0.84 | HTR1A (0.78) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL10725629 | 0.84 | HTR1A (0.78) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7977770 | 0.83 | SIGMAR1 (0.67) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL5425415 | 0.82 | KDM4E (0.70) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL1298887 | 0.82 | SIGMAR1 (0.73) | SIGMAR1MAPTNPSR1SLC6A2SLC6A4 | |
| SCHEMBL7991490 | 0.81 | SIGMAR1 (0.69) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL11107794 | 0.81 | CYP2C9 (0.57) | HTR1ADRD2ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660832-B1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMA INC (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5436246-A | Compounds for treatment of anxiety, depression, migraine, stroke, angina and hypertension | MERRELL DOW PHARMACEUTICALS INC. | 1995-07-25 | — | — | US | disclosed |
| EP-0660832-A1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006789-A1 | SEROTONIN RECEPTOR AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-31 | — | — | WO | disclosed |