Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.54 |
| ▸ | NQO2 | P16083 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 3/20 | 0.45 |
| ▸ | GABRD | O14764 | 3/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.45 |
| ▸ | GABRE | P78334 | 3/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27929617 | 0.86 | NQO2 (0.61) | GPR84NQO2PKMPKLRHTR2A | |
| SCHEMBL8425209 | 0.84 | NQO2 (0.55) | NQO2PKMPKLRGABRPGABRD | |
| SCHEMBL30029554 | 0.83 | GPR84 (0.64) | GPR84NQO2PKMPKLRHTR2A | |
| SCHEMBL28902316 | 0.83 | GPR84 (0.64) | GPR84NQO2PKMPKLRHTR2A | |
| SCHEMBL30844121 | 0.83 | NQO2 (0.54) | NQO2PKMPKLRGABRPGABRD | |
| SCHEMBL7087730 | 0.80 | THRA (0.48) | GPR84NQO2HTR2AMEN1KMT2A | |
| SCHEMBL4629902 | 0.80 | GPR84 (0.57) | GPR84NQO2HTR2AGABRPGABRD | |
| SCHEMBL7088540 | 0.79 | THRA (0.61) | GPR84HTR2AMEN1KMT2A | |
| SCHEMBL3294986 | 0.79 | NQO2 (0.64) | NQO2PKMPKLRHTR2AMEN1 | |
| SCHEMBL11537110 | 0.78 | NQO2 (0.63) | NQO2PKMPKLRHTR2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | disclosed |