Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.38 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088540 | 0.86 | THRA (0.61) | THRATHRBHTR2ALTA4HPLA2G2A | |
| SCHEMBL6512401 | 0.82 | THRB (0.54) | THRATHRBHTR2AGPR84MAPT | |
| SCHEMBL7084434 | 0.81 | LTA4H (0.50) | HTR2ALTA4HPLA2G2AMEN1KMT2A | |
| SCHEMBL8544378 | 0.80 | GPR84 (0.54) | HTR2AGPR84MEN1KMT2ASNCA | |
| SCHEMBL6516473 | 0.80 | THRA (0.54) | THRATHRBHTR2AGPR84MEN1 | |
| SCHEMBL6512774 | 0.80 | THRA (0.50) | THRATHRBHTR2ALTA4HPLA2G2A | |
| SCHEMBL7088062 | 0.80 | LTA4H (0.48) | HTR2ALTA4HPLA2G2AMEN1KMT2A | |
| SCHEMBL7082793 | 0.79 | LTA4H (0.48) | HTR2ALTA4HPLA2G2AMEN1KMT2A | |
| SCHEMBL7082617 | 0.78 | LTA4H (0.43) | HTR2ALTA4HPLA2G2AMEN1KMT2A | |
| SCHEMBL7088534 | 0.78 | HTR1B (0.48) | HTR2ALTA4HPLA2G2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |