Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2B | Q02880 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545090 | 0.86 | MALT1 (0.44) | TOP2BNPSR1ALDH1A1NQO1MALT1 | |
| SCHEMBL8542449 | 0.85 | TOP2B (0.49) | TOP2BNPSR1ALDH1A1NQO1MALT1 | |
| SCHEMBL8540942 | 0.84 | TOP2B (0.38) | TOP2BNPSR1ALDH1A1NQO1MALT1 | |
| Hydrochloric Acid SCHEMBL8545200 | 0.84 | TOP2B (0.48) | TOP2BNPSR1ALDH1A1NQO1MALT1 | |
| SCHEMBL4188736 | 0.84 | MALT1 (0.49) | TOP2BNPSR1ALDH1A1NQO1MALT1 | |
| Hydrochloric Acid SCHEMBL4197846 | 0.82 | MALT1 (0.47) | TOP2BNPSR1ALDH1A1NQO1MALT1 | |
| SCHEMBL8541343 | 0.81 | ECE1 (0.38) | TOP2BNPSR1ALDH1A1NQO1TOP2A | |
| SCHEMBL8544622 | 0.77 | KMT2A (0.61) | TOP2BNPSR1ALDH1A1NQO1TOP2A | |
| SCHEMBL4196694 | 0.76 | SMN1; SMN2 (0.53) | TOP2BNPSR1ALDH1A1NQO1MALT1 | |
| SCHEMBL4200289 | 0.76 | NPSR1 (0.44) | TOP2BNPSR1ALDH1A1NQO1MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639183-B1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA (IT) | 1998-07-01 | — | — | EP | disclosed |
| WO-1992015566-A1 | NITROGEN OXIDES OF AZA- AND DIAZA-ANTHRACENEDIONE DERIVATIVES AS ANTITUMOR AGENTS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-09-17 | — | — | WO | disclosed |