Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 4/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 12/20 | 0.40 |
| ▸ | ATF1 | P18846 | 9/20 | 0.40 |
| ▸ | JUN | P05412 | 4/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.39 |
| ▸ | RELA | Q04206 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | FOS | P01100 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2352666 | 0.88 | XPO1 (0.40) | XPO1ASPHKDM4ENFKB1ATF1 | |
| SCHEMBL3125739 | 0.85 | XPO1 (0.38) | XPO1ASPHKDM4ENFKB1ATF1 | |
| SCHEMBL3283505 | 0.81 | ASPH (0.42) | XPO1ASPHKDM4ENFKB1JUN | |
| SCHEMBL8546804 | 0.81 | NFKB1 (0.56) | XPO1ASPHKDM4ENFKB1ATF1 | |
| SCHEMBL9564859 | 0.81 | XPO1 (0.46) | XPO1ASPHKDM4ENFKB1ATF1 | |
| SCHEMBL480176 | 0.80 | XPO1 (0.62) | XPO1NFKB1ATF1JUNNFKB2 | |
| SCHEMBL2352570 | 0.80 | HPGD (0.53) | XPO1ASPHKDM4ENFKB1JUN | |
| SCHEMBL4415725 | 0.80 | KEAP1 (0.44) | XPO1ASPHNFKB1ATF1JUN | |
| SCHEMBL2118779 | 0.80 | KDM4E (0.47) | XPO1ASPHKDM4ENFKB1ATF1 | |
| SCHEMBL28044658 | 0.80 | ASPH (0.41) | XPO1ASPHKDM4ENFKB1JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811428-A | ADMINISTERING FOR THE TREATMENT AND PREVENTION OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-22 | — | — | US | disclosed |
| EP-0850228-A1 | PYRIMIDINE CARBOXAMIDES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997009315-A1 | PYRIMIDINE CARBOXAMIDES AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1997-03-13 | — | — | WO | disclosed |