Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASPH | Q12797 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FOS | P01100 | 3/20 | 0.36 |
| ▸ | JUN | P05412 | 3/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.36 |
| ▸ | RELA | Q04206 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.33 |
| ▸ | XPO1 | O14980 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544671 | 0.80 | XPO1 (0.42) | ASPHALDH1A1KMT2AFOSJUN | |
| SCHEMBL3283505 | 0.80 | ASPH (0.42) | ASPHALDH1A1KMT2AFOSJUN | |
| SCHEMBL4415725 | 0.79 | KEAP1 (0.44) | ASPHALDH1A1KMT2AFOSJUN | |
| SCHEMBL2352570 | 0.79 | HPGD (0.53) | ASPHALDH1A1KMT2AFOSJUN | |
| SCHEMBL17393706 | 0.77 | JUN (0.58) | ALDH1A1KMT2AFOSJUNNFKB1 | |
| SCHEMBL18660845 | 0.75 | HPGD (0.39) | ASPHALDH1A1KMT2AHPGDPOLB | |
| SCHEMBL22868013 | 0.75 | POLB (0.46) | ASPHALDH1A1KMT2AFOSJUN | |
| SCHEMBL14809757 | 0.75 | GABRP (0.45) | ASPHALDH1A1KMT2AFOSJUN | |
| SCHEMBL1759984 | 0.73 | PDE4B (0.40) | ASPHALDH1A1KMT2AFOSJUN | |
| SCHEMBL15639612 | 0.72 | CDK2 (0.46) | FOSJUNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105073715-B | The derovatives of dihydrogen dazin 3,5 | 中外制药株式会社 | 2017-12-01 | — | — | CN | disclosed |
| CN-105073715-A | Dihydropyridazine-3,5-dione derivative | CHUGAI PHARMACEUTICAL CO LTD | 2015-11-18 | — | — | CN | disclosed |