Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.55 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.55 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11220636 | 0.91 | ACHE (0.61) | ALDH1A1HPGD | |
| SCHEMBL10394036 | 0.86 | ACHE (0.65) | ALDH1A1HPGD | |
| SCHEMBL8870163 | 0.83 | SIGMAR1 (0.64) | ALDH1A1 | |
| SCHEMBL8545288 | 0.82 | GRIN1 (0.62) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL10392907 | 0.82 | ALDH1A1 (0.56) | ALDH1A1HPGD | |
| SCHEMBL8546370 | 0.80 | GRIN1 (0.82) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8871026 | 0.80 | SIGMAR1 (0.66) | GRIN2B | |
| SCHEMBL9464085 | 0.80 | ALDH1A1 (0.56) | ALDH1A1HPGD | |
| SCHEMBL11218131 | 0.78 | MEN1 (0.58) | GRIN2BGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL12123850 | 0.78 | ACHE (0.78) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |