Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | C3AR1 | Q16581 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541944 | 0.83 | CD274 (0.51) | ALDH1A1 | |
| SCHEMBL8541801 | 0.81 | GRIN2B (0.57) | POLBGRIN2BNPC1TDP1L3MBTL1 | |
| SCHEMBL8696687 | 0.81 | NPC1 (0.45) | GRIN2BNPC1TDP1HPGDSMN1; SMN2 | |
| SCHEMBL8540312 | 0.80 | GRIN2B (0.55) | POLBGRIN2BNPC1TDP1FAAH | |
| SCHEMBL8539669 | 0.80 | SIGMAR1 (0.47) | GRIN2B | |
| SCHEMBL2603249 | 0.78 | POLB (0.68) | POLBGRIN2BNPC1TDP1L3MBTL1 | |
| SCHEMBL8541116 | 0.78 | FAAH (0.57) | POLBGRIN2BNPC1TDP1SMN1; SMN2 | |
| SCHEMBL8541319 | 0.75 | HPGD (0.50) | POLBGRIN2BNPC1TDP1HPGD | |
| SCHEMBL8540140 | 0.74 | HPGD (0.57) | POLBGRIN2BNPC1TDP1HPGD | |
| SCHEMBL8538696 | 0.74 | FAAH (0.50) | POLBGRIN2BFAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705258-B1 | AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY | KNOLL AG (DE) | 1998-12-30 | — | — | EP | disclosed |
| EP-0705258-A1 | AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY | Knoll AG (DE) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000507-A1 | AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |