SCHEMBL8545697

SCHEMBL8545697

CN(C)c1cc(Oc2ccc(CNO)cc2)cc(Oc2ccc(CNO)cc2)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ST14 Q9Y5Y6 3/20 0.42
CALM1 P0DP23 1/20 0.38
KCNH2 Q12809 1/20 0.38
CARM1 Q86X55 1/20 0.37
PRMT6 Q96LA8 1/20 0.37
THRB P10828 1/20 0.37
IDO1 P14902 1/20 0.37
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NOS1 P29475 1/20 0.36
NOS2 P35228 1/20 0.36
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
MMP8 P22894 1/20 0.35
CACNA1B Q00975 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8545698 0.81 ALDH1A1 (0.49) ST14KDM4EALDH1A1HTTSMN1; SMN2
SCHEMBL8549943 0.81 SMN1; SMN2 (0.48) ST14CARM1PRMT6THRBIDO1
SCHEMBL8547795 0.78 CARM1 (0.52) ST14CARM1PRMT6THRBIDO1
SCHEMBL8544291 0.78 ST14 (0.46) ST14CARM1PRMT6THRBIDO1
SCHEMBL8546066 0.78 MTNR1A (0.47) KCNH2KDM4EALDH1A1HTTSMN1; SMN2
SCHEMBL8545423 0.78 SMN1; SMN2 (0.51) ST14THRBIDO1KDM4EALDH1A1
SCHEMBL20904516 0.77 ALDH1A1 (0.56) THRBIDO1KDM4EALDH1A1HTT
SCHEMBL27336667 0.75 THRB (0.45) THRBIDO1ALDH1A1SMN1; SMN2NOS1
SCHEMBL2218696 0.73 THRB (0.64) THRBIDO1KDM4EALDH1A1HTT
SCHEMBL8544608 0.73 ST14 (0.58) ST14CARM1PRMT6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed