Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 11/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8390257 | 0.89 | KIT (0.42) | GAALMNAKDM4EALDH1A1HPGD | |
| SCHEMBL8548702 | 0.88 | LMNA (0.45) | GAALMNAKDM4EALDH1A1HPGD | |
| SCHEMBL29445183 | 0.88 | BCHE (0.54) | KDM4EALDH1A1HPGDSMN1; SMN2ELANE | |
| SCHEMBL9089933 | 0.88 | BCHE (0.54) | KDM4EALDH1A1HPGDSMN1; SMN2ELANE | |
| SCHEMBL8545625 | 0.85 | KIT (0.42) | GAALMNAKDM4EALDH1A1HPGD | |
| SCHEMBL29860013 | 0.84 | KIT (0.41) | GAALMNAKDM4EALDH1A1HPGD | |
| SCHEMBL7840124 | 0.83 | GABRA1 (0.41) | GAALMNAKDM4EALDH1A1HPGD | |
| Dimethylamine SCHEMBL8546032 | 0.83 | KIT (0.44) | GAALMNAKDM4EALDH1A1HPGD | |
| Dimethylamine SCHEMBL7640258 | 0.82 | KIT (0.43) | GAALMNAKDM4EALDH1A1HPGD | |
| SCHEMBL7830488 | 0.82 | GABRA1 (0.42) | GAALMNAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591058-B1 | Ellipticine derivatives with antitumor activity | ADIR (FR) | 1998-06-03 | — | — | EP | disclosed |
| US-5498611-A | ANTITUMOR AGENTS | ADIR ET COMPAGNIE (FR) | 1996-03-12 | — | — | US | disclosed |
| US-5407940-A | Antitumor agents | ADIR ET COMPAGNIE (FR) | 1995-04-18 | — | — | US | disclosed |
| EP-0591058-A1 | Ellipticine derivatives with antitumor activity | ADIR ET COMPAGNIE (FR) | 1994-04-06 | — | — | EP | disclosed |