Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928062 | 0.92 | ALOX5 (0.47) | KRASMTNR1AMTNR1BHTR7MEN1 | |
| SCHEMBL2872712 | 0.90 | HTR7 (0.57) | MTNR1AMTNR1BHTR7MEN1KMT2A | |
| SCHEMBL7417377 | 0.88 | MAPT (0.49) | KRASMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL14876295 | 0.87 | ATM (0.55) | KRASMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL30672858 | 0.82 | PLG (0.46) | KRASHTR7KMT2APLGPLAU | |
| SCHEMBL2124040 | 0.82 | PLG (0.46) | KRASHTR7KMT2APLGPLAU | |
| SCHEMBL9479096 | 0.81 | HTR7 (0.53) | MTNR1AMTNR1BHTR7MEN1KMT2A | |
| SCHEMBL6384442 | 0.80 | MTNR1A (0.48) | MTNR1AMTNR1BMAPK1ALOX5EPHX2 | |
| SCHEMBL19148282 | 0.80 | MTNR1A (0.64) | MTNR1AMTNR1BMEN1KMT2ANPC1 | |
| SCHEMBL31735444 | 0.80 | MEN1 (0.46) | KRASMTNR1AMTNR1BHTR7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715627-B1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5744488-A | 1-CARBOXYALKYL-3-ALKYL OR PHENYL-5-ORGANOSULFONAMIDE OR -AMIDE INDOLES; ATHERSCLEROSIS; ANGINA; PREVENTING ANGIOPLASTY OCCULSION; THROMBOXANE SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-04-28 | — | — | US | disclosed |
| EP-0715627-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | Pfizer Limited (GB) | 1996-06-12 | — | — | EP | disclosed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | disclosed |