SCHEMBL8546451

SCHEMBL8546451

OC1CN(Cc2cc(OC3CCNCC3)nc(C(F)(F)F)c2)C1

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 14/20 0.45
AXL P30530 2/20 0.44
TYRO3 Q06418 2/20 0.44
MERTK Q12866 2/20 0.44
LOX P28300 4/20 0.42
SYK P43405 1/20 0.35
TIPARP Q7Z3E1 1/20 0.34
PIM1 P11309 1/20 0.34
LOXL3 P58215 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27315685 0.91 AXL (0.38) LOXL2AXLTYRO3MERTKLOX
SCHEMBL21128589 0.89 LOXL2 (0.43) LOXL2AXLTYRO3MERTKLOX
SCHEMBL8543452 0.86 LOXL2 (0.44) LOXL2AXLTYRO3MERTKLOX
SCHEMBL8579703 0.86 LOXL2 (0.44) LOXL2AXLTYRO3MERTKLOX
SCHEMBL22449698 0.85 LOXL2 (0.48) LOXL2AXLTYRO3MERTKLOX
SCHEMBL8530609 0.83 LOXL2 (0.42) LOXL2LOXSYK
SCHEMBL15390231 0.83 LOXL2 (0.44) LOXL2LOXSYKTIPARPPIM1
SCHEMBL30771875 0.81 LOXL2 (0.43) LOXL2MERTKLOXSYKTIPARP
SCHEMBL15390719 0.81 LOXL2 (0.43) LOXL2MERTKLOXSYKTIPARP
SCHEMBL9893726 0.81 PIM1 (0.33) LOXL2AXLTYRO3MERTKTIPARP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230027606-A1 BIOMARKERS FOR GRAFT-VERSUS-HOST DISEASE INCYTE CORPORATION 2023-01-26 US disclosed
US-11406640-B2 JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction INCYTE CORPORATION (US) 2022-08-09 US disclosed
WO-2022150676-A1 COMBINATION THERAPY COMPRISING JAK PATHWAY INHIBITOR AND ROCK INHIBITOR INCYTE CORPORATION (US) 2022-07-14 WO disclosed
US-11372003-B2 Biomarkers for graft-versus-host disease INCYTE CORPORATION (US) 2022-06-28 US disclosed
WO-2022125670-A1 JAK1 PATHWAY INHIBITORS FOR THE TREATMENT OF VITILIGO INCYTE CORPORATION (US) 2022-06-16 WO disclosed
WO-2022120131-A1 JAK INHIBITOR WITH A VITAMIN D ANALOG FOR TREATMENT OF SKIN DISEASES INCYTE CORPORATION (US) 2022-06-09 WO disclosed
US-20220175731-A1 JAK1 PATHWAY INHIBITORS FOR THE TREATMENT OF VITILIGO INCYTE CORPORATION 2022-06-09 US disclosed
WO-2021076124-A1 USE OF JAK1 INHIBITORS FOR THE TREATMENT OF CUTANEOUS LUPUS ERYTHEMATOSUS AND LICHEN PLANUS (LP) INCYTE CORPORATION (US) 2021-04-22 WO disclosed
WO-2021072098-A1 BIOMARKERS FOR GRAFT-VERSUS-HOST DISEASE INCYTE CORPORATION (US) 2021-04-15 WO disclosed
WO-2021072116-A1 BIOMARKERS FOR GRAFT-VERSUS-HOST DISEASE INCYTE CORPORATION (US) 2021-04-15 WO disclosed
WO-2016183063-A1 CRYSTALLINE FORMS OF A PI3K INHIBITOR INCYTE CORPORATION (US) 2016-11-17 WO disclosed
WO-2016183060-A1 PROCESS FOR THE SYNTHESIS OF A PHOSPHOINOSITIDE 3-KINASE INHIBITOR INCYTE CORPORATION (US) 2016-11-17 WO disclosed
WO-2016183062-A1 SALTS OF (S)-7-(1-(9H-PURIN-6-YLAMINO)ETHYL)-6-(3-FLUOROPHENYL)-3-METHYL-5H-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE INCYTE CORPORATION (US) 2016-11-17 WO disclosed
WO-2016138363-A1 SALTS OF PI3K INHIBITOR AND PROCESSES FOR THEIR PREPARATION INCYTE CORPORATION (US) 2016-09-01 WO disclosed
WO-2015191677-A1 BICYCLIC HETEROARYLAMINOALKYL PHENYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2015-12-17 WO disclosed
WO-2015184305-A1 TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 INCYTE CORPORATION (US) 2015-12-03 WO disclosed
WO-2015157257-A1 TREATMENT OF B-CELL MALIGNANCIES BY A COMBINATION JAK AND PI3K INHIBITOR INCYTE CORPORATION (US) 2015-10-15 WO disclosed
WO-2015131031-A1 JAK1 INHIBITORS FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROMES INCYTE CORPORATION (US) 2015-09-03 WO disclosed
WO-2015026818-A1 SURVIVAL BENEFIT IN PATIENTS WITH SOLID TUMORS WITH ELEVATED C-REACTIVE PROTEIN LEVELS INCYTE CORPORATION (US) 2015-02-26 WO disclosed
WO-2012068450-A1 CYCLOBUTYL SUBSTITUTED PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION (US) 2012-05-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11372003-B2 Biomarkers for graft-versus-host disease CD74, HLA-DRB1, TSG101 LOXL2 665/4885AXL 3610/4885TYRO3 671/4885
US-11406640-B2 JAK1 pathway inhibitors for the treatment of chronic lung allograft dysfunction JAK1, JAK3, STAT1 LOXL2 954/4885AXL 1375/4885TYRO3 212/4885
US-20220175731-A1 JAK1 PATHWAY INHIBITORS FOR THE TREATMENT OF VITILIGO JAK1, JAK3, JAK2 LOXL2 239/4885AXL 924/4885TYRO3 114/4885
US-20230027606-A1 BIOMARKERS FOR GRAFT-VERSUS-HOST DISEASE CD74, HLA-DRB1, TSG101 LOXL2 665/4885AXL 3610/4885TYRO3 671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.