Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | PHGDH | O43175 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547825 | 0.88 | SMN1; SMN2 (0.51) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL8550836 | 0.88 | TSHR (0.50) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL8549684 | 0.87 | ALDH1A1 (0.49) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL11457689 | 0.82 | TSHR (0.60) | MAPTLMNAPOLBPHGDHMEN1 | |
| SCHEMBL50994 | 0.82 | TSHR (0.54) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL4406921 | 0.81 | TSHR (0.50) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL8549114 | 0.80 | ALDH1A1 (0.45) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL14476851 | 0.80 | NR4A1 (0.55) | MAPTPOLBPHGDHTSHRBCL2L1 | |
| SCHEMBL1612393 | 0.79 | TSHR (0.51) | MAPTLMNAPOLBMEN1KMT2A | |
| SCHEMBL5863528 | 0.79 | TSHR (0.64) | MAPTLMNAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |