Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550836 | 0.89 | TSHR (0.50) | SMN1; SMN2NFKB1LMNATSHRALDH1A1 | |
| SCHEMBL8549684 | 0.88 | ALDH1A1 (0.49) | SMN1; SMN2GAARAB9ANPC1LMNA | |
| SCHEMBL8546609 | 0.88 | MAPT (0.50) | SMN1; SMN2NPC1LMNATSHRMAPT | |
| SCHEMBL9251907 | 0.85 | TDP1 (0.59) | SMN1; SMN2GAARAB9ANPC1NFKB1 | |
| SCHEMBL50994 | 0.83 | TSHR (0.54) | SMN1; SMN2NFKB1LMNATSHRALDH1A1 | |
| SCHEMBL8549114 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2NFKB1LMNATSHRALDH1A1 | |
| SCHEMBL26187377 | 0.81 | TSHR (0.60) | SMN1; SMN2GAARAB9ANPC1NFKB1 | |
| SCHEMBL5863528 | 0.80 | TSHR (0.64) | SMN1; SMN2GAANFKB1LMNATSHR | |
| SCHEMBL1612393 | 0.80 | TSHR (0.51) | SMN1; SMN2NFKB1LMNATSHRALDH1A1 | |
| SCHEMBL4415542 | 0.80 | TSHR (0.64) | SMN1; SMN2GAANFKB1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |