Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547825 | 0.89 | SMN1; SMN2 (0.51) | TSHRTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL8549684 | 0.88 | ALDH1A1 (0.49) | TSHRL3MBTL1ALDH1A1MAPTMAPK1 | |
| SCHEMBL8546609 | 0.88 | MAPT (0.50) | TSHRMAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL4415542 | 0.85 | TSHR (0.64) | TSHRTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL5863528 | 0.85 | TSHR (0.64) | TSHRTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL50994 | 0.85 | TSHR (0.54) | TSHRTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL27339443 | 0.84 | TDP1 (0.50) | TSHRTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL8399635 | 0.84 | TDP1 (0.57) | TSHRTDP1L3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL8549114 | 0.83 | ALDH1A1 (0.45) | TSHRTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL1612393 | 0.82 | TSHR (0.51) | TSHRTDP1L3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |