Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547337 | 0.91 | ALDH1A1 (0.43) | TRPM8RAB9ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL8549517 | 0.87 | ALDH1A1 (0.39) | TRPM8RAB9AL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL8545437 | 0.85 | ALDH1A1 (0.38) | RAB9ATSHRSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8545180 | 0.83 | ALDH1A1 (0.43) | TRPM8RAB9ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL8546689 | 0.76 | ALDH1A1 (0.43) | RAB9ANPC1ALDH1A1KMT2ALMNA | |
| SCHEMBL8546335 | 0.75 | HSD17B10 (0.44) | TRPM8TSHRL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL8543209 | 0.74 | TRPM8 (0.42) | TRPM8RAB9ATSHRL3MBTL1CASP3 | |
| SCHEMBL8663140 | 0.73 | TRPM8 (0.46) | TRPM8RAB9ATSHRL3MBTL1PRMT5 | |
| SCHEMBL8545401 | 0.73 | TRPM8 (0.40) | TRPM8RAB9ATSHRSMN1; SMN2NPC1 | |
| SCHEMBL10691483 | 0.71 | FFAR1 (0.58) | RAB9AL3MBTL1SMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714393-B1 | THIAZOLES AS ANTIVIRAL | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5789408-A | Antiviral thiazoles | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| WO-1995005378-A1 | ANTIVIRAL THIAZOLES | PFIZER INC. (US) | 1995-02-23 | — | — | WO | disclosed |