Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 9/20 | 0.43 |
| ▸ | EDNRA | P25101 | 6/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547930 | 0.95 | EDNRB (0.47) | EDNRBEDNRAPTPN1KDM4EMAPT | |
| SCHEMBL8548858 | 0.93 | EDNRB (0.45) | EDNRBEDNRAPTPN1CSF1RFFAR1 | |
| SCHEMBL8551472 | 0.92 | EDNRB (0.43) | EDNRBEDNRAPTPN1FFAR1PDCD1 | |
| SCHEMBL8547163 | 0.91 | EDNRB (0.45) | EDNRBEDNRAPTPN1KDM4E | |
| SCHEMBL8547478 | 0.90 | EDNRB (0.43) | EDNRBEDNRAPTPN1KDM4EMAPT | |
| SCHEMBL8549574 | 0.88 | EDNRB (0.43) | EDNRBEDNRAPTPN1KDM4EHTT | |
| SCHEMBL8548607 | 0.88 | EDNRB (0.45) | EDNRBEDNRAPDCD1CD274KDM4E | |
| SCHEMBL8551476 | 0.88 | EDNRB (0.48) | EDNRBEDNRACSF1RPLK1KDM4E | |
| SCHEMBL8549234 | 0.87 | EDNRB (0.52) | EDNRBEDNRAPTPN1KDM4EMAPT | |
| SCHEMBL8547864 | 0.87 | EDNRB (0.49) | EDNRBEDNRAPTPN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |