Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.40 |
| ▸ | GABRD | O14764 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5329933 | 0.85 | HTT (0.45) | HTTLMNATDP1MAPTMAPK1 | |
| SCHEMBL8547804 | 0.76 | NPC1 (0.41) | HTTMAPTMAPK1ALDH1A1CA9 | |
| SCHEMBL11561853 | 0.75 | CA9 (0.51) | HTTLMNATDP1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL8553027 | 0.75 | NPC1 (0.40) | HTTMAPTMAPK1ALDH1A1CA9 | |
| SCHEMBL7999688 | 0.74 | CA9 (0.50) | HTTLMNATDP1MAPTMAPK1 | |
| SCHEMBL8589137 | 0.74 | HTR6 (0.61) | LMNAMAPTALDH1A1CA9CA12 | |
| SCHEMBL8549838 | 0.72 | ALDH1A1 (0.47) | MAPTMAPK1ALDH1A1CA9CA12 | |
| SCHEMBL11233028 | 0.72 | KDM1A (0.53) | HTTLMNATDP1MAPTMAPK1 | |
| Formamide SCHEMBL28411125 | 0.70 | HTT (0.46) | HTTLMNATDP1MAPTMAPK1 | |
| SCHEMBL8549155 | 0.68 | CA12 (0.45) | HTTMAPTCA9CA12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |