Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 5/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542917 | 0.85 | GRIN2B (0.45) | LMNAGRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL8546435 | 0.81 | MEN1 (0.48) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL8541676 | 0.79 | GRIN2B (0.56) | LMNAGRIN2BATMALDH1A1 | |
| SCHEMBL8547729 | 0.78 | ALDH1A1 (0.47) | LMNAGRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL8873013 | 0.78 | LMNA (0.42) | LMNAGRIN2BKMT2AMEN1ATM | |
| SCHEMBL8545550 | 0.77 | GRIN1 (0.45) | LMNAGRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL8543096 | 0.77 | GRIN2B (0.47) | LMNAGRIN2BGRIN1GRIN2DGRIN3B | |
| SCHEMBL7246879 | 0.76 | DRD2 (0.54) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL8543235 | 0.75 | GRIN2B (0.66) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL8873050 | 0.75 | GRIN2B (0.52) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| US-5698553-A | Benzylpiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-16 | — | — | US | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |